Exogenous Biotin May Be Leading You Astray: A Novel Cause Of Factitious Neonatal Graves’ Disease
نویسندگان
چکیده
Neonatal Graves’ disease is a rare form of pediatric hyperthyroidism that occurs in 1-5% of infants born to mothers with Graves’ disease [1,2]. The risk of neonatal Graves’ disease is highest in those infants born to mothers with active or refractory Graves’ disease during pregnancy. However, infants whose mothers have undergone definitive therapy with either radioiodine ablation or surgical thyroidectomy can still be affected.
منابع مشابه
Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature.
CONTEXT Biotin (vitamin B7) is an essential co-factor for four carboxylases involved in fatty acid metabolism, leucine degradation, and gluconeogenesis. The recommended daily intake (RDI) of biotin is approximately 30 μg per day. Low-moderate dose biotin is a common component of multivitamin preparations, and high-dose biotin (10 000 times RDI) has been reported to improve clinical outcomes and...
متن کاملMEDICAL PRACTICE Occasional Survey Aetiology of Hyperthyroidism m*
Graves's disease (diffuse toxic goitre) Toxic nodular goitre Multinodular (Plummer's disease) Uninodular (toxic adenoma) Nodular goitre with Graves's disease Excess thyroid stimulating hormone Pituitary tumour Choriocarcinoma and hydatidiform mole Embryonal testicular carcinoma Other malignancy (?) Extraneous thyroid hormone Exogenous: Intentional factitious Overenthusiastic therapy During T-3 ...
متن کاملAnticardiolipin Antibodies and Immunoglobulin M and A in Graves’ Disease
Background: Graves’ disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves’ disease. Patients and methods: Anticardiolipin a...
متن کاملA Somewhat Bizarre Case of Graves Disease Due to Vitamin Treatment
Context Accurate measurements of circulating hormones is essential for the practice of endocrinology. Immunometric assays employing the streptavidin-biotin system are widely used to measure hormones. However, these assays are susceptible to interference in patients taking biotin supplementations. This interference could mimic a coherent hormone profile, leading to misdiagnosis and unnecessary t...
متن کاملBrief Reports Surfactant Therapy in Neonatal Respiratory Distress Syndrome
Respiratory distress syndrome (RDS) is the leading cause of neonatal respiratory distress in our country and is the commonest disorder requiring assisted ventilation all over the world(l,2), Exogenous surfactant administration is now an established mode of therapy in neonatal RDS (hyaline membrane disease, HMD). Ever since the first report of successful surfactant replacement therapy in neonate...
متن کامل